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Further changes involving receptor affinity and activation occurred specifically in monotremes

The cryo-EM structures of retatrutide-bound GLP-1R, GIPR and GCGR reveal a combination of conserved peptidereceptor interactions and receptor-specific conformations, particularly in ECL1, that enables retatrutide to execute agonism at multiple receptors

10.1016/j.cardfail.2007.06.721 63 MehtaS

doi: 10.1002/dmrr.2810 133 GlaesnerWVickAMMillicanREllisBTschangSHTianYet al